Role of Cardiolipin in Mitochondrial Signaling Pathways.

摘要: The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes and plays a role in many processes, including respiration energy conversion. Pathological changes CL amount or species composition can have deleterious consequences for function trigger the production reactive oxygen species. Signaling networks monitor adequate cellular response. Here, we summarize signaling pathways focus on tissues with high-energy demand, like heart. itself was recently identified as precursor formation lipid mediators. We highlight concept platform. exposed to outer membrane upon stress domains serve binding site events. During mitophagy, interacts players mitophagy Beclin 1 recruits autophagic machinery by its interaction LC3. Apoptotic require platform recruit apoptotic factors such tBid, Bax, caspase-8. required activation inflammasome inflammatory signaling. As has been observed diseases, described here may play general pathology.