Sarcomatous hepatocellular carcinoma: a special reference to ordinary hepatocellular carcinoma.
作者： HIDEHIRO NISHI , KEN-ICHI TAGUCHI , YOSHIKI ASAYAMA , SHIN-ICHI AISHIMA , KEISHI SUGIMACHI
DOI: 10.1046/J.1440-1746.2003.02888.X
关键词:
摘要: Background: Sarcomatous hepatocellular carcinoma (HCC) has a worse prognosis than ordinary HCC. The relationship between the malignant potential of sarcomatous HCC and cell proliferation or adhesion is unknown. This study was undertaken to clarify this relationship. Methods: In 21 cases HCC, including 16 surgically resected five autopsy cases, immunohistochemistry used compare component (s-comp) (o-comp) within each HCC. Results: We found 15 epithelial-cadherin (E-cadherin)-positive in o-comp (79%) nine positive s-comp (43%). difference E-cadherin-positive tumor prevalence significant (P < 0.05). Ki-67 (MIB1) labeling index ratio 127 ± 40 80 ± 33 o-comp, there greater tendency have an ability multiply (P = 0.096). Conclusion: indicated that loss E-cadherin related morphological alteration HCC; however, no respect found. © 2003 Blackwell Publishing Asia Pty Ltd
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sci-hub.se 参考文章(25)
B Gumbiner, Signal transduction of beta-catenin. Current Opinion in Cell Biology. ,vol. 7, pp. 634- 640 ,(1995) , 10.1016/0955-0674(95)80104-9
Atsushi Ochiai, Setsuo Hirohashi, Masatoshi Takeichi, Sayumi Shibamoto, Hikaru Matsuda, Fumiaki Ito, Shoichiro Tsukita, Yae Kanai, Tatsuya Oda, Tatsuya Oda, Shingo Akimoto, Kazuyoshi Yanagihara, Akira Nagafuchi, Tsukasa Oyama, A Truncated β-Catenin Disrupts the Interaction between E-Cadherin and α-Catenin: A Cause of Loss of Intercellular Adhesiveness in Human Cancer Cell Lines Cancer Research. ,vol. 54, pp. 6282- 6287 ,(1994)
Setsuo Hirohashi, Masatoshi Takeichi, Yukio Shimosato, Masayuki Noguchi, Osahiko Abe, Shinji Hirano, Yutaka Shimoyama, Cadherin Cell-Adhesion Molecules in Human Epithelial Tissues and Carcinomas Cancer Research. ,vol. 49, pp. 2128- 2133 ,(1989)
Hugh A. Edmondson, Paul E. Steiner, Primary carcinoma of the liver.A study of 100 cases among 48,900 necropsies Cancer. ,vol. 7, pp. 462- 503 ,(1954) , 10.1002/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E
Saburo Kakizoe, Masamichi Kojiro, Toshiro Nakashima, Hepatocellular carcinoma with sarcomatous change. Clinicopathologic and immunohistochemical studies of 14 autopsy cases Cancer. ,vol. 59, pp. 310- 316 ,(1987) , 10.1002/1097-0142(19870115)59:2<310::AID-CNCR2820590224>3.0.CO;2-S
Masamichi Kojiro, Shigetaka Sugihara, Saburo Kakizoe, Osamu Nakashima, Kazumitsu Kiyomatsu, Hepatocellular carcinoma with sarcomatous change: a special reference to the relationship with anticancer therapy. Cancer Chemotherapy and Pharmacology. ,vol. 23, ,(1989) , 10.1007/BF00647229
Jeanne Tran Van Nhieu, Claire Angélique Renard, Yu Wei, Daniel Cherqui, Elie Serge Zafrani, Marie Annick Buendia, Nuclear Accumulation of Mutated β-Catenin in Hepatocellular Carcinoma Is Associated with Increased Cell Proliferation American Journal of Pathology. ,vol. 155, pp. 703- 710 ,(1999) , 10.1016/S0002-9440(10)65168-1
Yoshiaki Nagamine, Kohsuke Sasaki, Kohhei Kaku, Manabu Takahashi, Hepatic sarcoma associated with hepatoma. Pathology International. ,vol. 28, pp. 645- 651 ,(1978) , 10.1111/J.1440-1827.1978.TB00903.X
Takuya Genda, Michiie Sakamoto, Takafumi Ichida, Hitoshi Asakura, Setsuo Hirohashi, Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells. Laboratory Investigation. ,vol. 80, pp. 387- 394 ,(2000) , 10.1038/LABINVEST.3780043
Jürgen Behrens, Jens P. von Kries, Michael Kühl, Laurakay Bruhn, Doris Wedlich, Rudolf Grosschedl, Walter Birchmeier, Functional interaction of β-catenin with the transcription factor LEF-1 Nature. ,vol. 382, pp. 638- 642 ,(1996) , 10.1038/382638A0