Electrical Detection of Femtomolar DNA via Gold‐Nanoparticle Enhancement in Carbon‐Nanotube‐Network Field‐Effect Transistors

摘要: The development of sequence-selective DNA sensors for diagnosis genetic or pathogenic disease has attracted increasing interest. Most detection methods rely on optical, piezoelectric, electrochemical transductions. Alternative based the resistance change a single silicon nanowire an individual carbon nanotube have been reported. However, these may significant deviceto-device variations and their fabrication requires high production costs. Recently, field-effect transistors (FETs) single-walled (SWNT) networks fabricated, electrical properties depend percolation paths SWNTs in conduction channels, where device are expected to be small. Label-free biomolecules using SWNT network FETs (SNFETs) successfully achieved, with typical limits order ca. 1 nM DNA. In this Communication, we report that sensitivity SNFETs can further improved 100 fM by ‘‘nanoparticle enhancement’’ approach, which target DNAs hybridized probe device, reporter labeled Au nanoparticles (AuNPs) flank segment sequence. We note enhancement incorporating (e.g., CdS Au) recently reported approaches. On