Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter
作者： A. H. M. AL-Faisal , I. J. AL-Ramahi , I. A. Abudl-Hassan , A. T. Hamdan , S. Barusrux
DOI: 10.1007/S00580-012-1572-9
关键词:
摘要: Sixty-three Arabic patients (16 males and 47 females) with thyroid toxic nontoxic goiter who attended the endocrinologist in Nuclear Medicine Hospital Al Yarmok Department Baghdad, Iraq were examined for peroxidase (TPO) gene mutations. A total of ten heterozygous mutations have been identified human TPO associated goiter. These involved transition or transversion cysteine either by thymine guanine at position 1708 exon 10 (c.1708C>T) 1978 11 (c.1978C>G). From a detected mutations, two c.1978C>G eight (two c.1708C>T six mutations) In conclusion, this study that not yet reported Iraq, most them are among females (90 %) adults age between 30 50 years old (80 %).
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