Losses of chromosomes 1p and 19q are rare in pediatric oligodendrogliomas

摘要: Pediatric oligodendrogliomas are rare neoplasms and have not been characterized extensively either pathologically or genetically. Given the recent interest in significance of chromosomal losses predicting clinical course establishing uniform diagnoses adult oligodendrogliomas, we reviewed pathological features a series pediatric determined their 1p 19q status using fluorescence situ hybridization. Of 19 tumors originally diagnosed as oligodendroglioma, 7 were 3 anaplastic oligoastrocytoma, 6 reclassified. Only one tumor, an had loss; none loss. The single patient whose tumor loss did particularly favorable course. These results suggest that arise by molecular alterations distinct from such do hold immediate promise adjunct to diagnosis oligodendrogliomas.