Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage.
作者： Hong Xu , Charles Boone , Hannah L. Klein
DOI: 10.1128/MCB.24.16.7082-7090.2004
关键词:
摘要: The SRS2 gene of Saccharomyces cerevisiae encoding a 3'-->5' DNA helicase is part the postreplication repair pathway and functions to ensure proper damage arising during replication through pathways that do not involve homologous recombination. Through synthetic array analysis, genes are essential when Srs2 absent have been identified. Among these MRC1, TOF1, CSM3, which mediate intra-S checkpoint response. srs2 Delta mrc1 lethality due inappropriate recombination, as can be suppressed by genetic elimination dependent on role Mrc1 in but independent Delta, tof1 csm3 mutants sister chromatid cohesion defects, implicating established at fork an important factor promoting stalled forks gap repair.
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