Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells.

摘要: Epithelial-mesenchymal transition (EMT) is a crucial step in tumor progression and has an important role during cancer invasion metastasis. Although fucosyltransferase IV (FUT4) been implicated the modulation of cell migration, metastasis, its EMT unclear. This study explores molecular mechanisms involvement FUT4 breast cells. Breast lines display increased expression FUT4, which accompanied by enhanced appearance mesenchymal phenotype can be reversed knockdown endogenous FUT4. Moreover, induced activation phosphatidylinositol 3-kinase (PI3K)/Akt, inactivation GSK3β nuclear translocation NF-κB, resulting Snail MMP-9 greater motility. Taken together, these findings indicate that through PI3K/Akt NF-κB signaling systems, induce key mediators facilitate acquisition phenotype. Our support possibility novel regulator cells promising target for therapy.