X-ray contrast medium containing liposome and method for preparation thereof

作者: Satoshi Kawakatsu , Chiaki Nagaike , Akihisa Nakajima , Eiichi Ueda

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摘要: An X-ray contrast medium which comprises liposome having a narrow particle diameter distribution, containing compound polyalkylene oxide group and/or sterol in its lipid membrane, and water-soluble nonionic iodine-containing included the water phase said wherein preferably both of membrane an aqueous medium, is dispersed, contain at least pharmaceutical preparation auxiliary substantially same concentration inside outside weight ratio 1 to 10 membrane. The above prepared by supercritical carbon dioxide method, therefore, free toxic solvent such as chlorine-containing solvent.

参考文章(6)
Tomohiro Imura, Hideki Sakai, Chihiro Kaise, Masatoshi Sakurai, Yoichiro Arai, Masahiko Abe, Katsuto Otake, Teruhisa Kaneko, Process for producing liposome and apparatus therefor ,(2001)
P RYAN, M DAVIS, D MELCHIOR, The preparation and characterization of liposomes containing X-ray contrast agents. Biochimica et Biophysica Acta. ,vol. 756, pp. 106- 110 ,(1983) , 10.1016/0304-4165(83)90029-6
Satoru Hashimoto, Katsuto Otake, 正彦 阿部, Masahiko Abe, 勝人 大竹, 悟 橋本, Method for producing liposome, cosmetic containing the liposome, and skin care preparation ,(2001)
Itou Tomoyoshi, Kubo Kazuhiro, Mitsuchika Kouzou, Yasukochi Toru, PHOSPHOLIPID MODIFIED BY POLYALKYLENE OXIDE, METHOD OF PRODUCING THE SAME AND USE THEREOF ,(2002)
Hitoshi Yamauchi, Shiro Miyoshi, Atsushi Sasaki, 宏 渡辺, Harutami Yamada, 英雄 金子, 治民 山田, 安理 森川, Naoichi Murahashi, Yasuri Morikawa, 直一 村橋, 勝利 青野, Kunio Azuma, Katsutoshi Aono, 詩郎 三好, 邦雄 東, Akira Nakabayashi, Hideo Kaneko, 暁 中林, 淳 佐々木, Hiroshi Watanabe, 仁史 山内, Production of liposome ,(1992)
Ono Mitsunori, PRODUCTION OF LIPOSOME ,(1989)