Chimeric glycoproteins containing immunogenic segments of human parainfluenza virus type 3.

作者: Michael W. Wathen

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摘要: This invention encompasses novel chimeric glycoproteins which are useful for preparing virus specific immune responses against human parainfluenza type 3, PIV3. Host cells transformed with structural genes coding the glycoproteins, expression and replication plasmids containing genes, vaccines made from methods protecting humans by inoculation said also part of this invention.

参考文章(15)
Richard W. Compans, Ranjit Ray, Viral glycoprotein subunit vaccine ,(1985)
K. L. van Wyke Coelingh, C. C. Winter, E. L. Tierney, W. T. London, B. R. Murphy, Attenuation of Bovine Parainfluenza Virus Type 3 in Nonhuman Primates and Its Ability to Confer Immunity to Human Parainfluenza Virus Type 3 Challenge The Journal of Infectious Diseases. ,vol. 157, pp. 655- 662 ,(1988) , 10.1093/INFDIS/157.4.655
Shinya Suzu, Yuko Sakai, Tatsuo Shioda, Hiroshi Shibuta, Nucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins Nucleic Acids Research. ,vol. 15, pp. 2945- 2958 ,(1987) , 10.1093/NAR/15.7.2945
Kathleen L. Van Wyke Coelingh, Brian R. Murphy, Peter L. Collins, Anne-Marie Lebacq-Verheyden, James F. Battey, Expression of biologically active and antigenically authentic parainfluenza Type 3 virus hemagglutinin-neuraminidase glycoprotein by a recombinant baculovirus Virology. ,vol. 160, pp. 465- 472 ,(1987) , 10.1016/0042-6822(87)90018-3
Kathleen L. Van Wyke Coelingh, Christine Winter, Brian R. Murphy, Antigenic variation in the hemagglutinin-neuraminidase protein of human parainfluenza type 3 virus Virology. ,vol. 143, pp. 569- 582 ,(1985) , 10.1016/0042-6822(85)90395-2