High Frequency of HBeAg-Negative Cases in Naive HBsAg-Positive Subjects with Chronic Hepatitis B Virus Infection Managed in the Yaoundé Hepatitis Therapeutic Committee: A Cross Sectional Study

摘要: The aim was to describe the epidemiology of chronic hepatitis B virus (HBV) infection within Yaounde Hepatitis Therapeutic Committee. Methods: This a cross-sectional study from June 2004 May 2012. We consecutively collected epidemiological data (gender, age, alanine amino- transferase-ALT, HBe-antigen-HBeAg, viral load-HBV-DNA and cirrhosis evaluation) naive surface antigen (HBsAg)-positive patients with HBV infection. Chronic is defined by persistence HBsAg for at least six months. level serum HBV-DNA determined COBAS-AmpliPrep Technical/COBAS-TaqMan ® 2.0 (Roche). Data were entered analyzed using SPSS 20.0 software (IBM Corporation, USA). Re- sults: Of 315 HBsAg-positive consulted, 74.6% male; mean (SD) age 35.04 (10.25) years. Nearly 92% HBeAg-negative. ALT normal in 63.2%; detected 81.0% ≤2000 IU/mL 65.9%. Liver biopsy performed 145 (46.03%); 10 (6.9%) had cirrhosis. HBeAg-negative older than HBeAg-positive (35.3 vs. 31.9 years; p = 0.006). high 84.0% 32.8% (p < 0.0001). 100% against 79.7% 0.05). median 1550 × 3 HBeAg- positive 1140 Cirrhosis diagnosed 15.4% 6.1% 0.221). Conclusion: negative cases are predominant among * Corresponding author.