The Dark Side of E2F1: In Transit beyond Apoptosis

摘要: E2F1 plays a critical role in cell-cycle progression and the induction of apoptosis response to DNA damage. The latest evidence has uncovered that this tumor suppressor is most relevant for cancer chemoresistance. Increased abundance triggers invasion metastasis by activating growth receptor signaling pathways, which turn promote an antiapoptotic environment. data shed light on molecular mechanisms underlying E2F1-induced prometastatic activity predict its radical switch from mediator cell death toward accelerator progression. This raises perspective new drug targets at late-stage cancer. Cancer Res; 72(3); 571–5. ©2012 AACR .