Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection.

摘要: BACKGROUND: One of the challenging aspects SARS-CoV-2 infection is its diverse multisystemic disease presentation. OBJECTIVES: To evaluate diagnostic value cutaneous manifestations and investigate their duration timing in relation to other COVID-19 symptoms. METHODS: We used data from 336 847 UK users COVID Symptom Study app assess body rash or an acral infection, independent online survey 11 544 respondents skin-specific symptoms collect photographs. RESULTS: Using app, we show significant association between skin rashes a positive swab test result (odds ratio 1·67, 95% confidence interval 1·42-1·97). Strikingly, among survey, found that 17% SARS-CoV-2-positive cases reported as first presentation, 21% only clinical sign COVID-19. Together with British Association Dermatologists, have compiled catalogue images most common 400 individuals (https://covidskinsigns.com), which made publicly available assist clinicians recognition this early feature CONCLUSIONS: Skin cluster symptoms, are predictive test, occur number cases, either alone before classical Recognizing important identifying new earlier