Near-field dynamics of high-speed spray dryer coannular two fluid nozzle: Effects of operational conditions and formulations
作者： Sadegh Poozesh , Stephen W. Grib , Michael W. Renfro , Patrick J. Marsac
DOI: 10.1016/J.POWTEC.2018.04.064
关键词:
摘要: Abstract The scaling-up of spray drying processes is an important and challenging step in commercializing specialty products with ensured quality because it mandates a comprehensive understanding several steps the process such as atomization, efficient solvent removal, particle segregation. formation needed sizes shapes impossible without appropriate atomization through dryer nozzles. Hence, research discussed that investigates mechanism for pilot scale externally-mixed, two-fluid nozzle by using time resolved particle-image velocimetry to study behavior droplets near-field tip. Important dynamics emanating from are described, characteristics formulations which widely used pharmaceutical industry. Spray angle, droplet breakup length, velocity distributions characterized. Understanding these parameters assists interpretation enables modeling process.
cheric.org参考文章(25)
Keith Masters, Spray drying handbook ,(1979)
Steve T. Wereley, Christian J. Kähler, Fulvio Scarano, Christian E. Willert, Jürgen Kompenhans, Markus Raffel, particle-image-velocimetry ,(2010)
Mehdi Jadidi, Sara Moghtadernejad, Ali Dolatabadi, A Comprehensive Review on Fluid Dynamics and Transport of Suspension/Liquid Droplets and Particles in High-Velocity Oxygen-Fuel (HVOF) Thermal Spray THE Coatings. ,vol. 5, pp. 576- 645 ,(2015) , 10.3390/COATINGS5040576
Anneleen Burggraeve, Tinne Monteyne, Chris Vervaet, Jean Paul Remon, Thomas De Beer, Process analytical tools for monitoring, understanding, and control of pharmaceutical fluidized bed granulation: a review European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 83, pp. 2- 15 ,(2013) , 10.1016/J.EJPB.2012.09.008
Yan Jin, Xiao Dong Chen, Numerical Study of the Drying Process of Different Sized Particles in an Industrial-Scale Spray Dryer Drying Technology. ,vol. 27, pp. 371- 381 ,(2009) , 10.1080/07373930802682957
E. Villermaux, H. Rehab, E. J. Hopfinger, Breakup régimes and self-sustained pulsations in coaxial jets Meccanica. ,vol. 29, pp. 393- 401 ,(1994) , 10.1007/BF00987574
Yanbin Huang, Wei-Guo Dai, Fundamental aspects of solid dispersion technology for poorly soluble drugs. Acta Pharmaceutica Sinica B. ,vol. 4, pp. 18- 25 ,(2014) , 10.1016/J.APSB.2013.11.001
Tawatchai Charinpanitkul, Wiwut Tanthapanichakoon, Poj Kulvanich, Kyo-Seon Kim, Granulation and tabletization of pharmaceutical lactose granules prepared by a top-sprayed fluidized bed granulator Journal of Industrial and Engineering Chemistry. ,vol. 14, pp. 661- 666 ,(2008) , 10.1016/J.JIEC.2008.03.005
Hai-Feng Liu, Wei-Feng Li, Xin Gong, Xian-Kui Cao, Jian-Liang Xu, Xue-Li Chen, Yi-Fei Wang, Guang-Suo Yu, Fu-Chen Wang, Zun-Hong Yu, Effect of liquid jet diameter on performance of coaxial two-fluid airblast atomizers Chemical Engineering and Processing. ,vol. 45, pp. 240- 245 ,(2006) , 10.1016/J.CEP.2005.08.003
Sandra Mandato, Eric Rondet, Guillaume Delaplace, Amal Barkouti, Laurence Galet, Philippe Accart, Thierry Ruiz, Bernard Cuq, Liquids' atomization with two different nozzles: Modeling of the effects of some processing and formulation conditions by dimensional analysis Powder Technology. ,vol. 224, pp. 323- 330 ,(2012) , 10.1016/J.POWTEC.2012.03.014