Micronutrients and host resistance to viral infection.

摘要: Previous work in our laboratory demonstrated that a virus could undergo rapid mutation host deficient Se, leading to normally avirulent acquiring virulence due genome changes. Once these mutations occur, even with adequate Se-nutriture is susceptible the newly virulent virus. What influence does deficiency Se have on immune response of host? Infection myocarditic strains coxsackievirus induces an inflammatory cardiac tissue. It this heart damage, rather than direct viral effects Chemokines are chemo-attractant molecules secreted during infection order attract cells site injury, and been found be important for development coxsackievirus-induced myocarditis. We influences expression mRNA chemokine monocyte protein-1, which may implications myocarditis Se-deficient host. Expression interferon-gamma was also greatly decreased animal. Thus, can profound as well itself. How alteration animal affects genotype remains answered.