Large Clinical Trials and Registries—Clinical Research Institutes

摘要: As medical practice enters the era of “evidence-based medicine,” there is a growing need for high-quality scientific evidence to inform decisions made by physicians and other health care providers. However, pressures on existing clinical research enterprise are mounting. New diagnostic therapeutic technologies continue drive up costs, while at same time, resources evaluating such increasingly constrained. Clinician-researchers therefore must have thorough grasp strengths limitations various methods be able critically evaluate apply approaches both traditional novel. In this chapter, we will explore history, background, general concepts before moving address how results investigations expressed. We also examine trial design; ethical, legal, organizational aspects conducting research; application statistical methods, including meta-analyses systematic reviews; integration these into practice. Finally, visit current controversies in some possibilities future.