Toenail cerium levels and risk of a first acute myocardial infarction: The EURAMIC and heavy metals study

摘要: The association between cerium status and risk of first acute myocardial infarction (AMI) was examined in a case-control study 10 centres from Europe Israel. Cerium toenails assessed by neutron activation analysis 684 cases 724 controls aged 70 years or younger. Mean concentrations were 186 173 lg/kg controls, respectively. positively associated with low socio-economic status, smoking, mercury, zinc scandium (p 6 0.001). Cases had significantly higher levels than after adjustment for age centre (case-control ratio 1.074; 95% CI 1.002–1.151) increased further other cardiovascular factors 1.085; 1.025–1.149. increasing trend = 0.02). After BMI, history hypertension, alcohol intake, diabetes, family CHD, b-carotene, lycopene, a-tocopherol, selenium, mercury scandium, the OR highest quintile 1.43 (95% 0.85–2.41; p-trend 0.08). When we applied this same model non-smokers odds ratios 4th 5th quintiles as compared lowest 2.09 1.05–4.16) 2.81 1.21–6.52), respectively, 0.011. Our results suggest that toenail may be an AMI, but more research is warranted to shed light fully understand plausibility public health implications these findings. � 2005 Published Elsevier Ltd.