The measurement and clinical relevance of brain atrophy in multiple sclerosis

摘要: Brain atrophy has emerged as a clinically relevant component of disease progression in multiple sclerosis. Progressive loss brain tissue bulk can be detected vivo sensitive and reproducible manner by MRI. Clinical studies have shown that begins early the course. The increasing amount data linking to clinical impairments suggest irreversible destruction is an important determinant greater extent than explained conventional lesion assessments. In this review, we will summarise proposed mechanisms contributing patients with We critically discuss wide range MRI-based methods used quantify regional whole-brain-volume loss. Based on review current information, rate among phenotypes for sclerosis, relevance atrophy, effect disease-modifying treatments its progression.