A chemical strategy to control protein networks in vivo
作者： Michael J. Ziegler , Klaus Yserentant , Volker Middel , Valentin Dunsing , Antoni J. Gralak
DOI: 10.1101/2020.04.08.031427
关键词:
摘要: ABSTRACT Direct control of protein interaction by chemically induced proximity (CIPP) holds great potential for cell- and synthetic biology as well therapeutic applications. However, toxicity, low cell-permeability lack orthogonality currently limit the use available chemical inducers (CIP). We present ‘Mandi’, a novel CIP demonstrate its applicability in cell culture systems living organisms translocation, network shuttling manipulation endogenous proteins.
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