Safety and efficacy of mycophenolate mofetil in treating neuromyelitis optica spectrum disorders: a protocol for systematic review and meta-analysis.

摘要: Introduction Neuromyelitis optica spectrum disorders (NMOSD) is an inflammatory and heterogeneous astrocyte disorder of the central nervous system with characteristic higher incidence in women Asian people. Most patients NMOSD have a course recurrence remission that prone to cause paralysis blindness. Several studies confirmed efficacy promising prospect mycophenolate mofetil (MMF) treatment NMOSD. Yet its therapeutic effect safety are controversial. Although there has been two published literature relevant topic this study, both them certain defects, they can only provide answers about or MMF from partial perspectives conclusions. This research aims perform direct comprehensive systematic review meta-analysis evaluate MMF’s effectiveness treating Methods analysis will cover all comparative researches, randomised controlled trials cohort studies, case–control study. A search be conducted PubMed, Web Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, Science Technology Journal Database Chinese Biomedical Literature their inception 31 June 2020. We also registers clinical trials, potential grey abstracts conferences. There no limits on language publication status. The reporting quality risk bias assessed by researchers independently. Expanded Disability Status Scales annualised relapse rate evaluated as primary outcome. secondary outcomes consist frequency severity adverse events, best-corrected visual acuity, relapse-free time next attack. performed using RevMan V.5.3 software provided Collaboration Stata V.12.0. Ethics dissemination Because data used for exclusively extracted ethical approval informed consent not required. peer-reviewed journal, presented at conferences shared social media platforms. PROSPERO registration number CRD42020164179.