Profiles of plasma estrogens, progesterone and their metabolites after oral or vaginal administration of estradiol or progesterone

摘要: Abstract Doses of 100 mg micronized progesterone (P) and 0.5 estradiol (E 2 ) were administered vaginally orally, respectively, in the early follicular phase menstrual cycle six premenopausal women. In second cycle, same doses subjects, orally for P E . Serial blood samples collected following steroids assayed by highly reliable techniques: P, , estrone 1 ), deoxycorticosterone (DOC), 5α- 5β-pregnanolone sulfates l DOC. Circulating levels higher after vaginal than oral administration, while those similar either route. Metabolites (DOC, DOCS pregnanolone) administration. Concerning estrogen sulfates, S concentrations whichever route, lower This study has confirmed that metabolism ingested occurs mainly intestine. Moreover, was predominantly metabolized to 5α-reduced derivatives, whatever route view metabolic pathways which are operative peripheral plasma found, appears be more adequate one hormone replacement therapy.