In vivo pharmacodynamic efficacy of gatifloxacin against Streptococcus pneumoniae in an experimental model of pneumonia: impact of the low levels of fluoroquinolone resistance on the enrichment of resistant mutants
作者： Delphine Croisier , Manuel Etienne , Lionel Piroth , Emilie Bergoin , Catherine Lequeu
DOI: 10.1093/JAC/DKH393
关键词:
摘要: Objectives: To investigate the impact of low levels fluoroquinolone resistance on emergence resistant mutants, we examined mutant selection window (MSW) hypothesis in experimental pneumonia rabbits infected with pneumococci various susceptibility to fluoroquinolones and treated gatifloxacin using a human-like regimen (equivalent 400 mg once daily). The MSW corresponds range concentrations between minimal inhibitory concentration (MIC) prevention (MPC), which is antibiotic that prevents mutants.
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