The innovation journey of genomics and asthma research

摘要: This article concerns the transformative potential of medical genomics for common disease research. We analysed 13 review articles in asthma research period 1999 to 2008. Our aim was understand how has emerged this field, and attendant changes. Motivated by Lippman’s geneticisation thesis, we use concept an ‘innovation journey’ trace expectations improved understanding, prevention, diagnosis treatment structure a dynamic co-evolutionary process through which genome-based discourse emerges. show researchers involved continuously struggle define their contribution research, as well clinical practice. Along way, propose changes both definition aetiological model asthma, thus highlighting gene–gene gene–environment interactions. It is, however, difficult characterise one geneticisation. With increasing attention being given epigenetics, metabolomics, proteomics systems biology, emerging picture suggests important, but much less deterministic, role genes