Aberrant p16 promoter methylation among Greek lung cancer patients and smokers: correlation with smoking.
作者： Elisavet Georgiou , Rozalia Valeri , Georgios Tzimagiorgis , Jacob Anzel , Dimitrios Krikelis
DOI: 10.1097/01.CEJ.0000236260.26265.D6
关键词:
摘要: Genetic and environmental factors (dietary smoking) influence lung cancer epidemiology induce epigenetic modifications that should be assessed in individual populations. We analyzed p16 methylation among Greek non-small cell carcinoma patients smokers using two-stage methylation-specific polymerase chain reaction. One hundred fifty specimens from cancerous adjacent non-cancerous tissue, bronchial washings sputum 48 specimens, mostly sputum, disease-free were included. was very frequent biopsies (82.85%) (non-small carcinoma, 80.35%; small 16.66%) patients, but also tissue (45.71 %). Concordance of positivity by cytological examination 51.78%. Methylation observed asymptomatic cytology-negative (22.5%) chronic obstructive pulmonary disease (three eight). Among individuals, correlated only with heavy smoking (>50 pack-years, P<0.001) differed male female smokers. In summary, is correlates cigarette consumption
auth.gr
sci-hub.se 参考文章(34)
Catherine A. Reznikoff, Frederic M. Waldman, Hidefumi Kinoshita, Somdatta Sarkar, Lorraine Meisner, David F. Jarrard, Gregg Magrane, Michael A. Newton, Thomas R. Yeager, Nadine Nassif, Yan Shi, p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells. Cancer Research. ,vol. 59, pp. 2957- 2964 ,(1999)
IVY H. N. WONG, Y. M. DENNIS LO, PHILIP J. JOHNSON, Epigenetic tumor markers in plasma and serum: biology and applications to molecular diagnosis and disease monitoring. Annals of the New York Academy of Sciences. ,vol. 945, pp. 36- 50 ,(2006) , 10.1111/J.1749-6632.2001.TB03862.X
Kara M. Doffek, William H. Westra, Manel Esteller, David Sidransky, Montserrat Sanchez-Cespedes, P. Anthony Decker, James G. Herman, Steven A. Ahrendt, Enas A. Alawi, Michael J. Demeure, Increased Loss of Chromosome 9p21 but not p16 Inactivation in Primary Non-Small Cell Lung Cancer from Smokers Cancer Research. ,vol. 61, pp. 2092- 2096 ,(2001)
Jian Yu, Min Ni, Jian Xu, Hongyu Zhang, Baomei Gao, Jianren Gu, Jianguo Chen, Lisheng Zhang, Mengchao Wu, Sushen Zhen, Jingde Zhu, Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer. ,vol. 2, pp. 29- 29 ,(2002) , 10.1186/1471-2407-2-29
Zhe Hou, Chung S. Yang, Ming Zhu Fang, Hong Lu, William Welsh, Yimin Wang, Ni Ai, Yi Sun, Tea Polyphenol (−)-Epigallocatechin-3-Gallate Inhibits DNA Methyltransferase and Reactivates Methylation-Silenced Genes in Cancer Cell Lines Cancer Research. ,vol. 63, pp. 7563- 7570 ,(2003)
Stephen B. Baylin, James G. Herman, Sanna K. Myöhänen, Hypermethylation Can Selectively Silence Individual p16ink4A Alleles in Neoplasia Cancer Research. ,vol. 58, pp. 591- 593 ,(1998)
Ming-Fang Wu, Ya-Wen Cheng, Ji-Ching Lai, Min-Chih Hsu, Jung-Ta Chen, Wen-Shan Liu, Ming-Chih Chiou, Chih-Yi Chen, Huei Lee, Frequent p16INK4a promoter hypermethylation in human papillomavirus-infected female lung cancer in Taiwan. International Journal of Cancer. ,vol. 113, pp. 440- 445 ,(2005) , 10.1002/IJC.20597
Ji-Ching Lai, Ya-Wen Cheng, Hui-Ling Chiou, Ming-Fang Wu, Chin-Yi Chen, Huei Lee, Gender difference in estrogen receptor alpha promoter hypermethylation and its prognostic value in non‐small cell lung cancer International Journal of Cancer. ,vol. 117, pp. 974- 980 ,(2005) , 10.1002/IJC.21278
S.Perwez Hussain, Lorne J Hofseth, Curtis C Harris, Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment Lung Cancer. ,vol. 34, pp. S7- S15 ,(2001) , 10.1016/S0169-5002(01)00339-7
Manel Esteller, James G. Herman, Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. The Journal of Pathology. ,vol. 196, pp. 1- 7 ,(2002) , 10.1002/PATH.1024