Stem Cell Pathways in Brain Tumors

摘要: Malignant brain tumors (including medulloblastoma, ependymoma, and high-grade gliomas) are among the most lethal cancers associated with poor survival rates despite advances in basic science clinical management. These surgically removed when possible treated radiation chemotherapy, however they often recur due to their infiltrative nature a fraction of cells that is refractory therapy. resistant have self-renewal properties along ability propagate heterogeneous tumor upon transplantation mouse model been termed cancer stem cells. Cancer within shown be therapies including chemotherapy rely on cell signaling pathways promote self-renewal. In addition tumors, identified variety other solid provide an additional conceptual link between developmental biology likely generate insight into both fields. Here we will discuss malignant update intrinsic extrinsic regulate maintenance, outline technology enrichment strategies for use genetic animal models.