Factors Predicting the Outcome of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 5-Year Retrospective Study.

摘要: Background: Clinicodemographic and laboratory parameters predicting the outcome of Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) may vary among populations owing to genotypic environmental variations. There is a scarcity studies evaluating these in Indian population. Aims: To analyze clinicodemographic disease patients SJS/TEN. Materials Methods: Clinical records admitted with diagnosis SJS/TEN from January 2014 December 2018 were reviewed retrospectively respect data pertaining details, parameters, outcome. Results: Of 51 included study, 24 (47.06%) females. Anticonvulsants [phenytoin (19.6%), carbamazepine (13.7%), others (5.88%)] most commonly implicated drugs followed by NSAIDs (19.6%). The overall mortality was 21.6% [SJS (0%), SJS-TEN overlap (18.8%), TEN (28.6%)]. mean detached body surface area (BSA) (35.4% ± 10.4% vs. 25.7% 11.8%; P = 0.02) significantly higher mortality. Blood urea nitrogen, serum HCO3− levels, random blood sugar associated Presence sepsis during course (9/12 2/39; 0.001). Other components SCORTEN like age heart rate not poor our study. None had malignancy. Conclusion: A BSA, presence sepsis, nitrogen sugar, lower levels Refinement scoring systems needed for better prognostication.