Uridine phosphorylase in biomedical, structural, and functional aspects: A review
作者： A. A. Lashkov , N. E. Zhukhlistova , T. A. Seregina , A. G. Gabdulkhakov , A. M. Mikhailov
DOI: 10.1134/S1063774511040122
关键词:
摘要: The activation of xenobiotics often causes malignant tumor cells to resist chemotherapeutic treatment. Uridine phosphorylase is the key enzyme pyrimidine metabolism and catalyzes reversible phosphorylation uridine with formation uracil ribose-1-phosphate. High-selectivity anticancer agents based on inhibitors are promising for treating both oncological infection diseases. New medicinal preparations can be predicted rationally developed only basis detailed biomedical, structural, functional knowledge about biomacromolecular target enzyme-drug complex.
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Timothy V. Pyrkov, Anton O. Chugunov, Nikolay A. Krylov, Dmitry E. Nolde, Roman G. Efremov, PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes. Bioinformatics. ,vol. 25, pp. 1201- 1202 ,(2009) , 10.1093/BIOINFORMATICS/BTP111
M. P. Liu, L. Beigelman, E. Levy, R. E. Handschumacher, G. Pizzorno, Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis. American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 274, ,(1998) , 10.1152/AJPGI.1998.274.6.G1018
Kenji Katsumata, Hidenori Tomioka, Tetsuo Sumi, Shinya Yamashita, Makoto Takagi, Fumiaki Kato, Ryuji Nakamura, Yasuhisa Koyanagi, Tatsuya Aoki, Kohichiro Kato, Correlation between clinicopathologic factors and kinetics of metabolic enzymes for 5-fluorouracil given to patients with colon carcinoma by two different dosage regimens. Cancer Chemotherapy and Pharmacology. ,vol. 51, pp. 155- 160 ,(2003) , 10.1007/S00280-002-0526-3
C. Heidelberger, L. Griesbach, O. Cruz, R. J. Schnitzer, E. Grunberg, Fluorinated pyrimidines. VI. Effects of 5-fluorouridine and 5-fluoro-2'-deoxyuridine on transplanted tumors. Experimental Biology and Medicine. ,vol. 97, pp. 470- 475 ,(1958) , 10.3181/00379727-97-23777
De Clercq E, Antiviral and antitumor activities of 5-substituted 2'-deoxyuridines. Methods and Findings in Experimental and Clinical Pharmacology. ,vol. 2, pp. 253- ,(1980)
Handschumacher Re, Sartorelli Ac, Sokoloski Ja, Lee Cw, Differentiation of HL-60 cells by dimethylsulfoxide activates a Na(+)-dependent nucleoside transport system. in Vivo. ,vol. 8, pp. 795- 801 ,(1994)
P. Cortes, F. Dumler, N. W. Levin, Glomerular uracil nucleotide synthesis. American Journal of Physiology-renal Physiology. ,vol. 255, ,(1988) , 10.1152/AJPRENAL.1988.255.4.F635
A. Zaniboni, The emerging role of 5-fluorouracil and leucovorin in the treatment of advanced breast cancer. A review. Journal of Chemotherapy. ,vol. 1, pp. 330- 337 ,(1989) , 10.1080/1120009X.1989.11738917
Delemarre Jf, Leyva A, Pinedo Hm, Lankelma J, Kraal I, High uridine phosphorylase activity in human melanoma tumor. Anticancer Research. ,vol. 3, pp. 227- 231 ,(1983)
Z. S. Veres, A. Szabolcs, G. Denes, I. Szinai, K. Ujszaszy, Biological activity of the potent uridine phosphorylase inhibitor 5-ethyl-2,2'-anhydrouridine. Drugs Under Experimental and Clinical Research. ,vol. 13, pp. 615- 621 ,(1987)