摘要: Caffeine, an antagonist of adenosine A1, A2A and A2B receptors, is known as adjuvant analgesic in combination with non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen humans. In preclinical studies, caffeine produces intrinsic antinociceptive effects several rodent models, augments the actions NSAIDs acetaminophen. Antagonism well inhibition cyclooxygenase activity at some sites, may explain actions. When combined morphine, can augment, inhibit or have no effect depending on dose, route administration, nociceptive test species; reflects spinal A1 while augmentation reflect noted above. Low doses given systemically antinociception by analgesics (acetaminophen, amitriptyline, oxcarbazepine, cizolirtine), probably reflecting block a component action involving receptors. Clinical studies demonstrated analgesia, treatment headache conditions, but not postoperative pain. Caffeine clearly exhibits complex pain transmission; knowledge such important for understanding analgesia considering situations which dietary intake impact regimens.
springer.com
sci-hub.se 参考文章(91)
Jager Lp, Seegers Aj, van Noordwijk J, Zandberg P, The anti-inflammatory, analgesic and antipyretic activities of non-narcotic analgesic drug mixtures in rats. Archives internationales de pharmacodynamie et de thérapie. ,vol. 251, pp. 237- 254 ,(1981)
GÜLAY Yaba, ZAFER Sezer, Y Tekol, None, Interaction between venlafaxine and caffeine on antinociception in mice. Die Pharmazie. ,vol. 61, pp. 60- 62 ,(2006)
J. Sawynok, Adenosine and ATP Receptors Handbook of experimental pharmacology. ,vol. 177, pp. 309- 328 ,(2006) , 10.1007/978-3-540-33823-9_11
A B Mauz, G Engelhardt, M Pairet, Role of caffeine in combined analgesic drugs from the point of view of experimental pharmacology. Drug Research. ,vol. 47, pp. 917- 927 ,(1997)
Catherine Ledent, Jean-Marie Vaugeois, Serge N. Schiffmann, Thierry Pedrazzini, Malika El Yacoubi, Jean-Jacques Vanderhaeghen, Jean Costentin, John K. Heath, Gilbert Vassart, Marc Parmentier, Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor Nature. ,vol. 388, pp. 674- 678 ,(1997) , 10.1038/41771
António F Ambrósio, Patrício Soares-da-Silva, Caetana M Carvalho, Arsélio P Carvalho, None, Mechanisms of Action of Carbamazepine and Its Derivatives, Oxcarbazepine, BIA 2-093, and BIA 2-024* Neurochemical Research. ,vol. 27, pp. 121- 130 ,(2002) , 10.1023/A:1014814924965
G. Castañeda‐Hernández, F. J. Flores‐Murrieta, F. J. López‐Muñoz, D. M. Flores‐Acevedo, Potentiation of the Analgesic Effect of Tolmetin, a Potent Non-steroidal Anti-inflammatory Drug, by Caffeine in the Rat Pharmacy and Pharmacology Communications. ,vol. 1, pp. 441- 444 ,(1995) , 10.1111/J.2042-7158.1995.TB00460.X
J Sawynok, M I Sweeney, T D White, Intracerebroventricular morphine releases adenosine and adenosine 3',5'-cyclic monophosphate from the spinal cord via a serotonergic mechanism. Journal of Pharmacology and Experimental Therapeutics. ,vol. 259, pp. 1013- 1018 ,(1991)
Loh Hh, Way El, Ho Ik, CYCLIC ADENOSINE MONOPHOSPHATE ANTAGONISM OF MORPHINE ANALGESIA Journal of Pharmacology and Experimental Therapeutics. ,vol. 185, pp. 336- 346 ,(1973)
J Sawynok, M I Sweeney, T D White, Involvement of adenosine in the spinal antinociceptive effects of morphine and noradrenaline. Journal of Pharmacology and Experimental Therapeutics. ,vol. 243, pp. 657- 665 ,(1987)