Divalent cation involvement in the action of Clostridium perfringens type A enterotoxin. Early events in enterotoxin action are divalent cation-independent.
作者： B A McClane , A P Wnek , K I Hulkower , P C Hanna
DOI: 10.1016/S0021-9258(18)69224-5
关键词:
摘要: Clostridium perfringens type A enterotoxin (CPE) is a membrane-active cytotoxin. There are number of recognized early steps in CPE cytotoxicity including binding to protein receptor, insertion into membranes, and CPE-mediated induction changes membrane permeability for small molecules such as ions amino acids. Further support the existence these further characterization events presented this report. We now report that action largely independent extracellular divalent cations. It also shown 3H-nucleotide release, known be later effect, Ca2+-dependent. model suggested involving two-step process with Ca2+-independent Ca2+-dependent late steps.
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