Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin.
作者： F Y Bois , B Eskenazi
DOI: 10.1289/EHP.94102476
关键词:
摘要: Abstract A recent study by Rier et al. showed that rhesus monkeys exposed daily for 4 years to 5 or 25 ppt of dioxin in food develop endometriosis, with incidence and severity related dose. We aimed determine whether the total time-integrated exposure a human population could be comparable Rier's monkeys. selected sample residents Seveso, Italy, who were acutely high levels following an accident 1976. conducted toxicokinetic analysis which takes into account species differences dose timing between humans The area under time-concentration curve fat, corresponds cumulative over time, ranges some most heavily Seveso from approximately 1.7 x 10(6) ppt-days 1.1 10(8) ppt-days. These values exceed all cases ppt. Given their exposure, should ideal epidemiologic cohort rule out confirm leads increased risk endometriosis humans.
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