Can Exercise Ameliorate Aromatase Inhibitor-Induced Cognitive Decline in Breast Cancer Patients?

摘要: Aromatase inhibitors (AIs) have been commonly used as an effective adjuvant therapy in treatment of breast cancer, especially for menopausal women with estrogen receptor-positive cancer. Due to the nature aromatase, key enzyme endogenous synthesis, inhibitory aromatase-induced side effects, such cognitive impairment has reported both human and animal studies. While extensive evidence suggested that physical exercises can improve learning memory activity even prevent age-related decline, basic research revealed some common pathways between exercise signaling affected function. This review draws on clinical studies assess potential impact function from treated AIs cancer explore mechanism effects estrogen-related cognition.