Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs.

摘要: Traveling through several time zones results in a constellation of symptoms known as jet lag. These include reduced alertness, daytime fatigue, loss appetite, cognitive skills, and disruption the sleep/wake cycle. In susceptible air travel passengers, lag may exacerbate affective illness result psychiatric morbidity. Dysregulation circadian rhythms melatonin secretion represent common underlying factor other disorders. Recent studies have established effectiveness strategically timed administration appropriate exposure to environmental schedules including light counteracting dysregulation (chronobiologic actions). With introduction melatonergic agonists such ramelteon tasimelteon, which both stronger affinity for MT₁ MT₂ receptors longer half-life, new therapeutic options now exist treating sleep disturbances associated with The analogs are unique inasmuch they can also enhance alertness. recently introduced antidepressant agomelatine, has its supremacy over antidepressants having significant chronobiologic activity, represents good choice depressive that