Assessment of left ventricular mechanics in patients with asymptomatic aortic regurgitation: a two-dimensional echocardiographic study.

摘要: We describe a noninvasive method for determining end-systolic meridional and circumferential wall stress left ventricular architecture as the ratio of muscle to cavity area. With this technique, which uses two-dimensional echocardiography cuff-determined values systolic blood pressure, we assessed in 15 normal subjects asymptomatic patients with severe chronic aortic regurgitation at rest after load manipulations sublingual nitroglycerin. Resting were increased (113.9 +/- 29 260 50.7 X 10(3) dynes/cm2) compared those (85.6 15.4 214.1 28.4 (both p less than .01) remained significantly greater Meridional obtained from echocardiographic studies correlated closely (r = .89) calculated simultaneously recorded M mode echocardiograms. Ejection fraction similar (55 10% vs 59 6%) unchanged by In spite mass (227 60 g 130 22 subjects), mass-to-volume area diastole lower (0.90 0.23 1.30 0.21 0.91 1.11 0.18 [p .005 .02]). These differences exaggerated nitroglycerin, while concomitant changes relative thickness virtually undetected echocardiography. Thus technique can be used early recognition afterload excess regurgitation. Furthermore, mean slopes stress-diameter stress-length lines, represent load-independent indexes myocardial contractile state, could group subjects, indicating that overall contractility was still normal. conclude stress, contractility, determined noninvasively. measurements may prove useful assessing primary or valvular heart disease their long-term management.