Targeting Glycolytic Adaptations of Cancer Cells: From Molecular Mechanisms to Therapeutic Opportunities
作者： Shanmugasundaram Ganapathy-Kanniappan
DOI: 10.1007/978-94-017-9421-3_15
关键词:
摘要: Metabolic reprogramming is one of the biochemical signatures cancer cells. Particularly, aerobic glycolysis (i.e. process conversion glucose into pyruvate followed by fermentation lactate even in presence oxygen) has been immense interest due to its impact not only on cells but tumor microenvironment as well. Conceptual advancement understanding oncogenic regulation and multifunctional properties glycolytic enzymes underscore relevance significance targeting This chapter will discuss, light recent research intricacies adaptation cells, rationale for exploiting it therapeutic intervention.
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