The Role of Bone Cells in Establishing the Hematopoietic Stem Cell Niche
作者： Joy Y. Wu , Henry M. Kronenberg
DOI: 10.1016/B978-0-12-375670-1.10004-4
关键词:
摘要: Publisher Summary Among mammalian stem cells, the best characterized are hematopoietic cells (HSCs). Stem have unique properties of self-renewal and multipotency, ability to use for therapeutic purposes holds tremendous appeal. Therefore, regulatory mechanisms governing cell function an area great scientific public interest. A single HSC can reconstitute entire system in vivo, HSCs been used with clinical benefit bone marrow transplantation. Maintenance differentiation dependent upon presence a supportive microenvironment, or niche. In adult mammals, takes place within cavity, Schofield first proposed concept microenvironment over 30 years ago. The appearance hematopoiesis bones coincides onset mineralization during skeletal development, recent decades, it has become apparent that marrow, surrounding non-hematopoietic tissues, play active role regulating hematopoiesis. stromal environment comprises multitude cellular components, including fibroblasts, endothelial adipocytes, osteoblasts. addition, lineage themselves likely also regulate microenvironment. This chapter highlights data regarding osteoblast
sci-hub.se 参考文章(108)
P. Chanson, A. Lomri, P. J. Marie, C. de Pollak, Increased proliferation of osteoblastic cells expressing the activating Gs alpha mutation in monostotic and polyostotic fibrous dysplasia. American Journal of Pathology. ,vol. 150, pp. 1059- 1069 ,(1997)
RH Lambertsen, L Weiss, A model of intramedullary hematopoietic microenvironments based on stereologic study of the distribution of endocloned marrow colonies Blood. ,vol. 63, pp. 287- 297 ,(1984) , 10.1182/BLOOD.V63.2.287.287
RS Taichman, MJ Reilly, SG Emerson, Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures Blood. ,vol. 87, pp. 518- 524 ,(1996) , 10.1182/BLOOD.V87.2.518.BLOODJOURNAL872518
BI Lord, NG Testa, JH Hendry, The relative spatial distributions of CFUs and CFUc in the normal mouse femur Blood. ,vol. 46, pp. 65- 72 ,(1975) , 10.1182/BLOOD.V46.1.65.65
M A Maloney, H M Patt, Bone marrow regeneration after local injury: a review. Experimental Hematology. ,vol. 3, pp. 135- 148 ,(1975)
Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan, Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. ,vol. 393, pp. 382- 386 ,(1998) , 10.1038/30756
Yi Tang, Xiangwei Wu, Weiqi Lei, Lijuan Pang, Chao Wan, Zhenqi Shi, Ling Zhao, Timothy R Nagy, Xinyu Peng, Junbo Hu, Xu Feng, Wim Van Hul, Mei Wan, Xu Cao, TGF-Β1-induced migration of bone mesenchymal stem cells couples bone resorption with formation Nature Medicine. ,vol. 15, pp. 757- 765 ,(2009) , 10.1038/NM.1979
Raymond Schofield, The relationship between the spleen colony-forming cell and the haemopoietic stem cell Blood cells. ,vol. 4, pp. 7- 25 ,(1978)
Fumio Arai, Hiroki Yoshihara, Kentaro Hosokawa, Yuka Nakamura, Yumiko Gomei, Hiroko Iwasaki, Toshio Suda, Niche Regulation of Hematopoietic Stem Cells in the Endosteum Annals of the New York Academy of Sciences. ,vol. 1176, pp. 36- 46 ,(2009) , 10.1111/J.1749-6632.2009.04561.X
Takashi Nagasawa, Microenvironmental niches in the bone marrow required for B-cell development Nature Reviews Immunology. ,vol. 6, pp. 107- 116 ,(2006) , 10.1038/NRI1780