The transplanted liver graft is capable of clearing asymmetric dimethylarginine.

摘要: Asymmetric dimethylarginine (ADMA) has been recognized as an endogenous inhibitor of the arginine–nitric oxide (NO) pathway. Its concentration is tightly regulated by urinary excretion and degradation enzyme dimethylaminohydrolase (DDAH), which highly expressed in liver. Considering liver a crucial organ clearing ADMA, we hypothesized increased ADMA levels during hepatic failure and, consequently, decline concentrations after successful transplantation. The aim present study was to investigate role metabolism patients undergoing In this prospective study, investigated course 42 transplantation results showed that preoperative were higher with acute (1.26 μmol/L, P < .001) chronic (.69 compared healthy volunteers (.41 μmol/L). addition, decreased from day first postoperative both (ΔADMA: −.63 = .005) group −0.15 .001). Furthermore, who experienced rejection, whole month nonrejectors (P .012). Moreover, 11 13 rejectors (85%) clear increase preceded onset episode confirmed biopsy. conclusion, our indicate transplanted graft quickly capable suggesting preservation DDAH. posttransplantation period reflect serious dysfunction rejection. (Liver Transpl 2004;10:1524–1530.)