Synthesis of 1,2,3,4‐Tetrahydro‐4‐oxothieno[3,2‐d]pyrimidine and Perhydropyrimidine Derivates from Alkyl Dicyanoacetates
作者： Richard Neidlein , Zhihua Sui
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摘要: Nucleophilic addition of methyl 3-aminothiophene-2-carboxylate (2) as well β-alanine ethyl ester (11) to one CN group the salts 1 alkyl dicyanoacetates, followed by cyclization, yielded 1,2,3,4-tetrahydro-4-oxothieno[3,2-d]pyridimine derivatives 6–10 (Scheme 1) and perhydropyrimidine 17–19 2), respectively.
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