Tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica Lam.

摘要: To develop a novel anti-cancer drug of low side effect against lung adenocarcinoma, the authors screened bioresources Okinawa Island, Japan. The medicinal plant Toddalia asiatica Lam. contained three benzo[c]phenanthridine derivatives: dihydronitidine (DHN), nitidine (NTD) and demethylnitidine (DMN). Of derivatives, DHN had been shown to selectively inhibit growth cancer cells in our previous study. Because similar molecular topology NTD or DMN DHN, it can be expected that also show selective cytotoxicity. aim present study was therefore examine cytotoxicity these two compounds vitro vivo. Benzo[c]phenanthridine derivatives were isolated from T. Lam., their chemical structures identified by interpretation NMR MS spectrum. compounds, evaluated for as well reduced murine human adenocarcinoma with intracellular accumulation. has proven highly effective vivo both subcutaneous xenograft model without any deteriorating effect. In contrast, no suggesting 8-methoxy group is critical structural feature This thus proves effectiveness agent first time, discusses mechanisms responsible