Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH.

摘要: Abstract Fifty-eight patients with severe, progressive multiple sclerosis were prospectively randomized to one of three treatments: 20 received intravenous ACTH, high-dose cyclophosphamide plus and 18 placed on a regimen consisting plasma exchange, low-dose oral cyclophosphamide, ACTH. The groups similar in age, sex, duration type disease, degree disability. Before treatment six months year after treatment, disability-status score, ambulation index, functional-status score determined, quantitative neurologic examination was performed. In the ACTH group, number stabilized or improved 8 at 4 year; cyclophosphamide-ACTH 16 exchange 11 9 year. High-dose most effective halting progression disease bot...