Clot properties and cardiovascular disease

摘要: Fibrinogen is cleaved by thrombin to fibrin, which provides the blood clot with its essential structural backbone. As an acute phase protein, plasma levels of fibrinogen are increased in response inflammatory conditions. In addition levels, fibrin structure altered a number factors. These include treatment common cardiovascular medications, such as aspirin, anticoagulants, statins and fibrates, well metabolic disease states diabetes mellitus hyperhomocysteinaemia. vitro studies can provide information regarding fibre density, porosity, mechanical strength fibres fibrinolysis. A change structure, denser smaller pores more resistant lysis, strongly associated disease. This pathological present patients arterial venous diseases, also found moderate form relatives Pharmacological therapies, aimed at both prophylaxis disease, appear result positive changes structure. such, therapies 'normalising' may be benefit prevention