Genetic approaches to autonomic dysreflexia

摘要: Autonomic dysreflexia is a potentially life-threatening condition in which episodic hypertension occurs after injuries above the mid-thoracic segments of spinal cord. Despite seriousness this condition, little known molecular mechanisms that lead to its development. The completed sequencing mouse genome, dense genetic map, and large repository engineered spontaneous mutants, make an ideal model organism study underlying autonomic dysreflexia. We subjected two wild-type strains mice, 129Sv C57BL/6, one mutant, Wallerian degeneration slow (Wld s), cord transection clip-compression injury. found incidence greatly reduced, compared cord-transected Wld s mice both injury paradigms C57BL/6 have undergone also amplitude dysreflexic response was greater cord-compressed than mice. These results implicate axonal as important source signals trigger development are discussed context genetics, interstrain differences possible