Altered Protein and Gene Expression of Beclin-1 Correlates with Poor Prognosis of Hcv-Associated Hepatocellular Carcinoma in Egyptian Patients.

摘要: Autophagy modulation has recently been addressed as a novel target for overcoming therapeutic resistance in hepatocellular carcinoma (HCC) to currently available anti-HCC therapy. The aim of this study was investigate the protein and gene expression Beclin-1 its correlation with prognosis HCV-associated HCC Egyptian patients. This prospective included 50 patients HCV-associated-HCC, treated surgical resection. Immunohistochemistry antibody quantitative real-time PCR were assessed liver tissues HCC. A normal-like pattern found 100% adjacent tissues, while three various patterns recognized: negative [18 (36%)], over [16 (32%)] normal (p=0.001). mRNA correlated coefficient 0.774 (p <0.001). Patients had significantly poor overall survival rates compared <0.007), which confirmed by multivariate analysis (p=0.01). Over-expression associated vascular invasion <0.003). However, high tumor histological grade, focal lesion multiplicity, presence involved margin or cirrhosis insignificantly related Becin-1. altered an important role development