A useful technique using imaging mass spectrometry for detecting the skin distribution of topically applied lidocaine
作者： Shosho Kijima , Hiroaki Todo , Yumi Matsumoto , Ryosuke Masaki , Wesam R. Kadhum
DOI: 10.1016/J.JDDST.2016.04.004
关键词:
摘要: Abstract The skin disposition of topically applied lidocaine hydrochloride was determined in steady-state permeation conditions by mass spectrometry imaging (MSI). distribution pig ear assessed using matrix-assisted laser desorption/ionization–time-of-flight (MALDI-TOF-MS) with images examined BioMap software. Following the detection intrinsic signals lidocaine, concentration–distance curve obtained brightness analysis ([M+H+]: m / z 235.18). Although concentration profile MALDI-TOF-MS did not completely correspond calculated from profile, could be detected. These results demonstrated that MSI might a useful method to determine non-radiolabeled or non-fluorescent drugs.
core.ac.uk
sci-hub.se 参考文章(24)
R. J. Scheuplein, I. H. Blank, Permeability of the skin Physiological Reviews. ,vol. 51, pp. 702- 747 ,(1971) , 10.1152/PHYSREV.1971.51.4.702
Peter Sjövall, Tanja M. Greve, Susanne K. Clausen, Kristian Moller, Stefan Eirefelt, Björn Johansson, Kim T. Nielsen, Imaging of Distribution of Topically Applied Drug Molecules in Mouse Skin by Combination of Time-of-Flight Secondary Ion Mass Spectrometry and Scanning Electron Microscopy Analytical Chemistry. ,vol. 86, pp. 3443- 3452 ,(2014) , 10.1021/AC403924W
Christian Surber, Klaus‐P. Wilhelm, David Bermann, Howard I. Maibach, In Vivo Skin Penetration of Acitretin in Volunteers Using Three Sampling Techniques Pharmaceutical Research. ,vol. 10, pp. 1291- 1294 ,(1993) , 10.1023/A:1018961511730
Lynn K. Pershing, Barbara S. Silver, Gerald G. Krueger, Vinod P. Shah, Jerome P. Skelley, Feasibility of measuring the bioavailability of topical betamethasone dipropionate in commercial formulations using drug content in skin and a skin blanching bioassay Pharmaceutical Research. ,vol. 9, pp. 45- 51 ,(1992) , 10.1023/A:1018975626210
Ingo Alberti, Yogeshvar N. Kalia, Aarti Naik, Richard H. Guy, Assessment and prediction of the cutaneous bioavailability of topical terbinafine, in vivo, in man. Pharmaceutical Research. ,vol. 18, pp. 1472- 1475 ,(2001) , 10.1023/A:1012217209228
Urpo Kiistala, Suction Blister Device for Separation of Viable Epidermis from Dermis* Journal of Investigative Dermatology. ,vol. 50, pp. 129- 137 ,(1968) , 10.1038/JID.1968.15
Christian Surber, Klaus‐P. Wilhelm, Mitsuhiko Hori, Howard I. Maibach, Richard H. Guy, Optimization of topical therapy: partitioning of drugs into stratum corneum. Pharmaceutical Research. ,vol. 7, pp. 1320- 1324 ,(1990) , 10.1023/A:1015958526423
Yogeshvar N Kalia, Ingo Alberti, Nabila Sekkat, Catherine Curdy, Aarti Naik, Richard H Guy, Normalization of Stratum Corneum Barrier Function and Transepidermal Water Loss In Vivo Pharmaceutical Research. ,vol. 17, pp. 1148- 1150 ,(2000) , 10.1023/A:1026474200575
Amy M Judd, David J Scurr, Jon R Heylings, Ka-Wai Wan, Gary P Moss, None, Distribution and Visualisation of Chlorhexidine Within the Skin Using ToF-SIMS: A Potential Platform for the Design of More Efficacious Skin Antiseptic Formulations Pharmaceutical Research. ,vol. 30, pp. 1896- 1905 ,(2013) , 10.1007/S11095-013-1032-5
Sindy Trauer, Alexa Patzelt, Nina Otberg, Fanny Knorr, Christel Rozycki, Gabor Balizs, Rolf Büttemeyer, Michael Linscheid, Manfred Liebsch, Jürgen Lademann, Permeation of topically applied caffeine through human skin – a comparison of in vivo and in vitro data British Journal of Clinical Pharmacology. ,vol. 68, pp. 181- 186 ,(2009) , 10.1111/J.1365-2125.2009.03463.X