DELLA and EDS1 Form a Feedback Regulatory Module to Fine-Tune Plant Growth–Defense Tradeoff in Arabidopsis

摘要: Abstract Plants maintain a dynamic balance between growth and defense , optimize allocation of resources for survival under constant pathogen infections. However, the underlying molecular regulatory mechanisms, especially in response to biotrophic bacterial infection, remain elusive. Here, we demonstrate that DELLA proteins and EDS1, an essential resistance regulator, form central module modulating plant growth–defense tradeoffs via direct interaction. When infected by Pst DC3000, EDS1 rapidly promotes salicylic acid (SA) biosynthesis resistance-related gene expression prime response, while infection stabilizes RGA RGL3 restrict a partially EDS1-dependent manner, which facilitates plants develop pathogens. increasingly accumulated DELLAs interact with suppress SA overproduction excessive response. Taken together, our findings reveal DELLA–EDS1-mediated feedback loop subtle avoid or attack.