Representativeness of patients enrolled in a primary care clinical trial for heavy/problem substance use.

摘要: BACKGROUND The extent to which participants in randomized clinical trials (RCTs) resemble their broader target groups is of particular concern when studying stigmatized conditions such as substance use disorders (SUDs). present study compared patients who enrolled a 4-arm trial SBIRT (screening, brief intervention, and referral treatment) with eligible declined participation. METHODS Participants (N = 1338) were primary care anonymously completed computer-delivered health survey screened positive for heavy/problem alcohol or drug use. Those consented the RCT (n = 713) those (n = 625) on variety demographic, use, psychosocial characteristics. Variables significant at P < .20 univariate analyses then examined using multivariate logistic regression determine combined effect. RESULTS sample was 60% female 76% African American, mean age 45.2 years. Patients participate differed from 34 (60%) 57 variables studied. most parsimonious model by found that older, more likely be unemployed, endorse prescription misuse, problems related family history problems, trouble falling asleep, professional recommendation lose weight. CONCLUSION consenting reported greater number severe mental than If higher level risk among other studies well, it would raise questions regarding generalizability results clinic samples.