The origin of recurrent translocations in recombining lymphocytes: a balance between break frequency and nuclear proximity.

摘要: Translocations occur through the aberrant joining of large stretches non-contiguous chromosomal regions. The substrates for these illegitimate rearrangements can arise as a result damage incurred during normal cellular processes, such transcription and replication, or action genotoxic agents. In lymphocytes many translocations bear signs having originated from abnormalities introduced programmed recombination. Although recombination is tightly controlled at different levels, mistakes leading to cytogenetic anomalies that include deletions, insertions, amplifications translocations, which are an underlying cause leukemias lymphomas. this review we focus on recent studies provide insight into origins two lymphocyte specific events: V(D)J class switch (CSR).