Bronchodilation and bronchoprotection in asthmatic preschool children from formoterol administered by mechanically actuated dry-powder inhaler and spacer.

摘要: We evaluated the bronchodilatory and bronchoprotective effect of long-acting β2-agonist formoterol administered as dry powder from a mechanically actuated dry-powder inhaler (DPI) using spacer in 12 asthmatic children 2 to 5 yr age. Lung function was measured specific airway resistance (sRaw) whole body plethysmograph. Hyperventilation cold, air used bronchial challenge, responsiveness estimated change sRaw. The Turbohaler 9 μ g compared with salbutamol 200 placebo at 15 min, 4 8 h postdose randomized, double-blind, placebo-controlled, crossover study. All treatments were DPI (Turbohaler) into spacer. Formoterol caused similar significant bronchodilation first measurement 3 min postdose. offered sustained stable for least h. Salbutamol provided less than ...