Anaesthetic and cardiorespiratory effects of a constant-rate infusion of alfaxalone in desflurane-anaesthetised sheep.

摘要: A prospective, randomised, blinded controlled study was performed to determine the anaesthetic and cardiorespiratory effects of a constant-rate infusion (CRI) alfaxalone in 12 sheep anaesthetised with desflurane, undergoing experimental orthopaedic surgery. Sheep were sedated dexmedetomidine (4 μg/kg, intravenously) butorphanol (0.3 mg/kg, intravenously). Anaesthesia induced (1 mg/kg/minute effect, maintained desflurane oxygen and alfaxalone 0.07 mg/kg/minute or saline for 150 minutes (range 150–166 minutes). The induction dose alfaxalone, expiratory fraction required maintenance, measurements blood-gases recorded at predetermined intervals. Quality sedation, recovery assessed. 1.7 mg/kg (1.2 2.6 mg/kg). lower (22 per cent) sheep receiving CRI (P = 0). Also, heart rate (P = 0), cardiac index (P = 0.002), stroke (P = 0) contractility higher, systemic vascular resistance (P = 0.002) lower. Although respiratory tended be higher there no difference PCO 2 between groups. Recovery times significantly longer given (25.4 v 9.5 minutes) but quality similar. Alfaxalone reduced requirements similar function, time more prolonged.