Molecular genetics of cytochrome P450 IID. Anomalies of drug metabolism.

摘要: Drugs are most often hydrophobic substances which, after their administration, must be transformed into hydrophilic compounds in order to facilitate urinary and biliary elimination (1,2). The hepatic metabolism of drugs xenobiotics is classically divided two successive phases. In the course phase I, undergo oxidation reduction reactions hydrolysis. This first metabolic step, referred as funtionalization, largely dominated by catalyzed cytochromes P450 whose characteristic property power metabolize a wide variety substrates, endogenous steroids, drugs, exogenous (1,3). These can lead formation reactive compounds, toxic, accumulation dangerous for organism (4). second