Development, intra-gastric performance and pharmacokinetic study of gastroretentive drug delivery system for cefdinir in human volunteers

摘要: The objective of this study was to develop sustained-release floating tablets cefdinir (CFDN) using effervescent technique prolong gastric residence time (GRT) and compare their pharmacokinetics with immediate release (IR) conventional sustained (SR) tablets. were designed CaCO 3 as gas-former three grades polyethylene oxide release-retardants further evaluated for physical characters, in vitro drug buoyancy studies. optimized formulation (F3) found be physically stable when stored at 40 o C/75% RH months. In vivo radiographic imaging F3 revealed a mean GRT 4.83 ± 0.57 h (n=3). Comparative pharmacokinetic performed F3, IR SR CFDN humans. Based on performance, the difference between t max , AUC 0-∞ 1/2 MRT statistically significant (p < 0.05). C tablet significant, but not significant. relative bioavailability 1.71 fold 1.24 SR. This improved is due combined effect increased GRT.