A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytes
作者： Jennifer K. Thompson , Tony Triglia , Michael B. Reed , Alan F. Cowman
DOI: 10.1046/J.1365-2958.2001.02484.X
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摘要: Summary Invasion of the merozoite form Plasmodium falciparum into human erythrocytes involves multiple receptor‐ligand interactions. The EBA175 protein P. has been shown to be ligand that binds a sialic acid-dependent site on glycophorin A. We have identified novel ligand, termed erythrocyte-binding antigen 140 (EBA140), shares structural features and homology with EBA175. Subcellular localization EBA140 suggests it is located in micronemes, same as receptor surface erythrocytes. Binding this erythrocyte sensitive neuraminidase resistant trypsin, proteinase K pronase. proteaseresistant properties not A or C. Additionally, analysis mutant from humans does bind B. Interestingly, we parasite line lacks eba140 gene, suggesting essential for vitro invasion. These results suggest may involved invasion using
sci-hub.se 参考文章(43)
Dror I. Baruch, Xin C. Ma, Hardeep B. Singh, Xiahui Bi, Brittan L. Pasloske, Russell J. Howard, Identification of a Region of PfEMP1 That Mediates Adherence of Plasmodium falciparum Infected Erythrocytes to CD36: Conserved Function With Variant Sequence Blood. ,vol. 90, pp. 3766- 3775 ,(1997) , 10.1182/BLOOD.V90.9.3766
A. R. Dluzewski, L. H. Bannister, The ultrastructure of red cell invasion in malaria infections: a review. Blood cells. ,vol. 16, pp. 257- 292 ,(1990)
Lúcio H. Freitas-Junior, Emmanuel Bottius, Lindsay A. Pirrit, Kirk W. Deitsch, Christine Scheidig, Francoise Guinet, Ulf Nehrbass, Thomas E. Wellems, Artur Scherf, Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum Nature. ,vol. 407, pp. 1018- 1022 ,(2000) , 10.1038/35039531
J. Alexandra Rowe, Joann M. Moulds, Christopher I. Newbold, Louis H. Miller, P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1 Nature. ,vol. 388, pp. 292- 295 ,(1997) , 10.1038/40888
S. Bowman, D. Lawson, D. Basham, D Brown, T. Chillingworth, C. M. Churcher, A. Craig, R. M. Davies, K. Devlin, T. Feltwell, S. Gentles, R. Gwilliam, N. Hamlin, D. Harris, S. Holroyd, T. Hornsby, P. Horrocks, K. Jagels, B. Jassal, S. Kyes, J. McLean, S. Moule, K. Mungall, L. Murphy, K. Oliver, M. A. Quail, M.-A. Rajandream, S. Rutter, J. Skelton, R. Squares, S. Squares, J. E. Sulston, S. Whitehead, J. R. Woodward, C. Newbold, B. G. Barrell, The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum Nature. ,vol. 400, pp. 532- 538 ,(1999) , 10.1038/22964
B K Sim, P A Orlandi, J D Haynes, F W Klotz, J M Carter, D Camus, M E Zegans, J D Chulay, Primary structure of the 175K Plasmodium falciparum erythrocyte binding antigen and identification of a peptide which elicits antibodies that inhibit malaria merozoite invasion. Journal of Cell Biology. ,vol. 111, pp. 1877- 1884 ,(1990) , 10.1083/JCB.111.5.1877
Margaret E. Perkins, Elizabeth H. Holt, Erythrocyte receptor recognition varies in Plasmodium falciparum isolates. Molecular and Biochemical Parasitology. ,vol. 27, pp. 23- 34 ,(1988) , 10.1016/0166-6851(88)90021-7
W Trager, J. Jensen, Human malaria parasites in continuous culture Science. ,vol. 193, pp. 673- 675 ,(1976) , 10.1126/SCIENCE.781840
Stephen A. Dolan, Jo Lynn Proctor, David W. Alling, Yasuto Okubo, Thomas E. Wellems, Louis H. Miller, Glycophorin B as an EBA-175 independent Plasmodium falciparum receptor of human erythrocytes Molecular and Biochemical Parasitology. ,vol. 64, pp. 55- 63 ,(1994) , 10.1016/0166-6851(94)90134-1
G Chu, D Vollrath, R. Davis, Separation of large DNA molecules by contour-clamped homogeneous electric fields Science. ,vol. 234, pp. 1582- 1585 ,(1986) , 10.1126/SCIENCE.3538420